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Steglujan (ertugliflozin / sitagliptin) approved by EMA for the treatment of type 2 diabetes

Steglujan is a medicine used to control blood glucose (sugar) levels in adults with type 2 diabetes. It is used together with diet and exercise in the following patients:

  • patients whose blood glucose levels are not satisfactorily controlled with the diabetes medicines metformin and/or a sulphonylurea, in combination with either ertugliflozin or sitagliptin;
  • patients who are already taking ertugliflozin and sitagliptin as separate tablets.

Steglujan contains the active substances ertugliflozin and sitagliptin.

Steglujan is available as tablets in 2 strengths of ertugliflozin and sitagliptin (5 mg/100 mg and 15 mg/100 mg) and can only be obtained with a prescription.

The recommended starting dose is one 5 mg/100 mg tablet taken once a day. In patients whose blood sugar needs further control, the dose can be increased to one 15 mg/100 mg tablet once a day.

Type 2 diabetes is a disease in which the body does not make enough insulin to control the level of glucose in the blood or when the body is unable to use insulin effectively. The result is a high level of glucose in the blood. The two active substances in Steglujan work in different ways to lower glucose levels:

Ertugliflozin helps to lower blood glucose by making the patient pass out glucose in the urine. It does this by blocking a protein in the kidneys (called SGLT2) that normally takes glucose back into the blood from the kidneys.

Sitagliptin blocks the breakdown of incretin hormones in the body. These hormones stimulate the pancreas to produce insulin. Prolonging the action of incretin hormones makes the pancreas produce more insulin when blood glucose levels are high. Sitagliptin also reduces the amount of glucose made by the liver, by increasing insulin levels and decreasing the levels of the hormone glucagon.

Together, these actions reduce blood glucose levels and help to control type 2 diabetes.

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