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SOLIRIS (eculizumab) – Alexion

Soliris is a pharma product indicated for the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH) to reduce hemolysis.

 

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, life-threatening disease of the blood characterized by destruction of red blood cells by thecomplement system, a part of the body’s intrinsic immune system. This destructive process is a result of a defect in the formation of surface proteins on the red blood cell, which normally function to inhibit such immune reactions. Since the complement cascade attacks the red blood cells throughout the circulatory system, the hemolysis is considered an intravascular hemolytic anemia. Other key features of the disease, notably the high incidence of thrombosis, are not totally understood.

PNH is the only hemolytic anemia caused by an acquired (rather than inherited) intrinsic defect in the cell membrane (deficiency of glycophosphatidylinositol leading to absence of protective proteins on the membrane). It may develop on its own (“primary PNH”) or in the context of other bone marrow disorders such as aplastic anemia (“secondary PNH”). Only a minority (26%) have the telltale red urine in the morning that originally gave the condition its name.[4]

Allogeneic bone marrow transplantation is the only curative therapy, but has significant rates of both mortality and ongoing morbidity. The monoclonal antibodyeculizumab is effective at reducing the need for blood transfusions and improving quality of life.[5] It, however, does not appear to change the risk of death or blood clots and has an extremely high price, with a single year of treatment costing at least $440,000. Soliris is available only through specialized wholesalers in Switzerland and all around the world.